HOXA13 directly regulatesEphA6 andEphA7 expression in the genital tubercle vascular endothelia
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چکیده
منابع مشابه
HOXA13 Is Essential for Placental Vascular Patterning and Labyrinth Endothelial Specification
In eutherian mammals, embryonic growth and survival is dependent on the formation of the placenta, an organ that facilitates the efficient exchange of oxygen, nutrients, and metabolic waste between the maternal and fetal blood supplies. Key to the placenta's function is the formation of its vascular labyrinth, a series of finely branched vessels whose molecular ontogeny remains largely undefine...
متن کاملA novel duplication in the HOXA13 gene in a family with atypical hand-foot-genital syndrome.
Hypospadias, when the urethral opening is located on the ventral side of the penis, is one of the most common congenital malformations with an incidence of 3 per 1000 males. Hypospadias is considered a complex trait caused by several genetic and environmental factors; low birth weight, for example, is associated with an increased risk for hypospadias. Most cases of hypospadias are sporadic but ...
متن کاملTranscriptional control of occludin expression in vascular endothelia: regulation by Sp3 and YY1.
Endothelium differentiates in response to tissue-specific signals; brain endothelium expresses tight junctions and transporters which are absent from other endothelia. The promoter of the tight junction protein occludin exhibited strong activity in a brain endothelial cell line, hCMEC/D3 but was inactive in lung endothelial cells. Expression of occludin in brain endothelium corresponded with bi...
متن کاملBAC transgenic analysis reveals enhancers sufficient for Hoxa13 and neighborhood gene expression in mouse embryonic distal limbs and genital bud.
We previously demonstrated that a approximately 1 Mb domain of genes upstream of and including Hoxa13 is co-expressed in the developing mouse limbs and genitalia. A highly conserved non-coding sequence, mmA13CNS, was shown to be insufficient in transgenic mice to direct precise Hoxa13-like expression in the limb buds or genital bud, although some LacZ expression from the transgene was reproduci...
متن کاملNovel HOXA13 mutations and the phenotypic spectrum of hand-foot-genital syndrome.
Hand-foot-genital syndrome (HFGS) is a rare, dominantly inherited condition affecting the distal limbs and genitourinary tract. A nonsense mutation in the homeobox of HOXA13 has been identified in one affected family, making HFGS the second human syndrome shown to be caused by a HOX gene mutation. We have therefore examined HOXA13 in two new and four previously reported families with features o...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2007
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.21077